Application and Effectiveness of Chinese Medicine in Regulating Immune Checkpoint Pathways

作     者：XIONG Luo-jie TIAN Yue-feng ZHAI Chun-tao LI Wei XIONG Luo-jie;TIAN Yue-feng;ZHAI Chun-tao;Li Wei

作者机构：College of AcupunctureMassage and RehabilitationHunan University of Chinese MedicineChangsha(410208)China Second Clinical CollegeShanxi University of Chinese MedicineJinzhongShanxi Province(030619)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2023年第29卷第11期

页      面：1045-1056页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(Nos.82174504,81674062) the Innovation Fund of Postgraduate,Hunan University of Chinese Medicine(No.2022CX20) 

主　　题：acupuncture herbal Immune 

摘      要：Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment,representing the forefront of antitumor ***,studies on immune checkpoint molecules have mainly focused on targeted *** medicine(CM)research as a complementary medicine has revealed that immune checkpoint molecules also undergo disease-specific changes in the context of autoimmune *** review article presents a comprehensive analysis of CM studies on immune checkpoint molecules in the last 5 years,with a focus on their role in different diseases and treatment *** research predominantly utilizes oral administration of herbal plant extracts or acupuncture techniques,which stimulate the immune system by activating specific acupoints through temperature and *** this study,we analyzed the modulation and mechanisms of immune checkpoint molecules associated with different coinhibitory and costimulatory molecules,and reviewed the immune functions of related molecules and CM studies in treating autoimmune diseases and *** summarizing the characteristics and research value of CM in regulating immune checkpoint molecules,this review aims to provide a useful reference for future studies in this field.