Composite B-cell and T-cell lymphomas:clinical,pathological,and molecular features of three cases and literature review

作     者：Xueli JIN Hui LIU Jing LI Xibin XIAO Xianggui YUAN Panpan CHEN Boxiao CHEN Yun LIANG Fengbo HUANG Xueli JIN;Hui LIU;Jing LI;Xibin XIAO;Xianggui YUAN;Panpan CHEN;Boxiao CHEN;Yun LIANG;Fengbo HUANG

作者机构：Department of Hematologythe Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of Pathologythe Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of Nuclear Medicinethe Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China School of MedicineZhejiang UniversityHangzhou 310029China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第8期

页      面：711-722页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0836[工学-生物工程] 071003[理学-生理学] 

基　　金：supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY166) the Natural Science Foundation of Zhejiang Province(No.LQ23H080003),China 

主　　题：Composite lymphoma B-cell lymphoma T-cell lymphoma 

摘      要：Composite lymphoma(CL)involving B-cell lymphoma and T-cell lymphoma is extremely ***,we report three such cases using immunohistochemistry,flow cytometry,and the next-generation sequencing(NGS)to identify the pathological and molecular characteristics of *** the first case,the patient was admitted to hospital for generalized pruritic maculopapular rash over the whole *** excisional biopsy of the skin lesions showed T-cell *** the same time,the staging bone marrow(BM)biopsy revealed a diffuse large B-cell lymphoma(DLBCL).After R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone)therapies,the patient produced a good response with substantial dissipation of the rashes and relief of *** other two patients were admitted to hospital due to lymphadenopathy and were diagnosed with DLBCL and follicular lymphoma(FL)after core needle biopsy of lymph nodes,BM biopsy,BM aspiration,and flow *** R-CHOP and R-COP(rituximab,cyclophosphamide,vincristine,and prednisone)therapies,they achieved complete remission unconfirmed(CRu)and complete remission(CR).However,one or two years later,they suffered a relapse of *** shocking fact was that re-biopsy of lymphadenopathy revealed peripheral T-cell lymphoma(PTCL)and angioimmunoblastic T-cell lymphoma(AITL).NGS findings identified DNA methyltransferase 3a(DNMT3a),isocitrate dehydrogenase 2(IDH2),Ras homolog gene family,member A(RHOA),splicing factor 3B subunit 1(SF3B1),and tumor protein p53(TP53)*** immunochemotherapy,these patients achieved CRu and CR ***,they suffered a second relapse of T-cell ***,they died due to progression of *** found that the occurrence of CL is associated with Epstein-Barr virus infection and DNMT3a,IDH2,and TP53 mutations,and the prognosis of the disease is closely related to the T-cell lymphoma components.