Preparation of a pH-sensitive pantoprazole-imprinted polymer and evaluation of its drug-binding and-releasing properties

作     者：MOHAJERI Seyed Amin SAJADI TABASSI Sayyed Abolghasem HASSANPOUR MOGHADAM Maryam MOHAJERI Seyed Ahmad 

作者机构：Pharmaceutical Research CenterSchool of PharmacyMashhad University of Medical Sciences Targeted Drug Delivery Research CenterSchool of PharmacyMashhad University of Medical Sciences 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2014年第57卷第6期

页      面：857-865页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：the Vice Chancellor of Research Mashhad University of Medical Sciences for financial support through Grant 89434 

主　　题：loading molecularly imprinted polymer pantoprazole release protective effect 

摘      要：The aim of this work was to synthesize a pantoprazole-imprinted polymer(MIPs)and study its binding and release properties in an aqueous *** acid(MAA),methacrylamide(MAAM),hydroxyethyl methacrylate(HEMA),and 4-vinyl pyridine(4VP)were tested as functional *** solvents were also applied as polymerization media under heat or UV *** optimized MIP was prepared in chloroform as a solvent,4-vinyl pyridine as a functional monomer,and ethylene glycole dimethacrylate(EGDMA)as a crosslinker monomer under UV *** and release properties of MIP were studied in comparison with a non-imprinted polymer(NIP)in aqueous media,at different pH *** protective effect of polymer for drugs against acidic conditions was evaluated at pH *** indicated that the MIP had superior binding properties compared to NIP for *** percentage of drug released from MIP was significantly less than from NIP at all pH values,which was attributed to the presence of imprinted cavities in the MIP *** also had a stronger protective effect for pantoprazole in acidic media,in comparison with NIP.