Synthesis and application of novel P-chiralmonophosphorus ligands

作     者：Xiaoxiao Xie Sanliang Li Qiaoyu Chen Hao Guo Junfeng Yang Junliang Zhang 

作者机构：Department of ChemistryFudan University2005 Songhu RoadShanghai200438China Academy for Engineering and TechnologyFudan UniversityShanghai200438China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第6期

页      面：1589-1592页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：funding support of the NSFC(22031004,21921003,and 21901043),STCSM(21ZR1445900) Shanghai Municipal Education Commission(20212308). 

主　　题：phosphorus palladium chiral 

摘      要：A series of novel P-stereogenic monophosphorus ligands (Xie-phos) were synthesized via the hydrophosphinylation of alkynes with secondary phosphine oxides by palladium catalysis and the following basemediated cyclization. They are easily synthesized and modified. Their utility was demonstrated in catalyticasymmetric reactions, including α-arylation of amides and the domino Heck/Suzuki reaction with moderate enantioselectivity.