Three new pyrrole alkaloids from the endophytic fungus Albifimbria viridis

作     者：Pan-Pan Wei Jia-Cheng Ji Xu-Jun Ma Zheng-Hui Li Hong-Lian Ai Xin-Xiang Lei Ji-Kai Liu 

作者机构：School of Pharmaceutical SciencesSouth-Central University for NationalitiesWuhan 430074People’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2022年第12卷第1期

页      面：51-55页

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China (31870513) Zheng-Hui Li,National Aerospace Science Foundation of China (32000011),Hong-Lian Ai 

主　　题：Pyrrole alkaloids Coptis chinensis Endophytic fungus Albifimbria viridis Immunosuppressive activity 

摘      要：Three new pyrrole alkaloids albifipyrrols A-C(1-3),were isolated from the endophytic fungus Albifimbria viridis col-lected from the Chinese medicinal *** structures were elucidated by extensive NMR and HRESIMS spectro-metric *** compounds were evaluated for immunosuppressive ***,compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC50 value 16.16μM.