Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant

作     者：Gen Li Meixing Yu Qiong Ke Jing Sun Yanwen Peng Chuanfeng Xiong Olivia Monteiro COVID-Infection and Immunity Investigation Group Jincun Zhao Andy P.Xiang Gen Li;Meixing Yu;Qiong Ke;Jing Sun;Yanwen Peng;Chuanfeng Xiong;Olivia Monteiro;COVID-19 Infection and Immunity Investigation Group;Jincun Zhao;Andy P.Xiang

作者机构：Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina Center for Stem Cell Biology and Tissue EngineeringKey Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhouChina State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina Center for Biomedicine and InnovationsFaculty of MedicineMacao University of Science and TechnologyMacaoChina 不详 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第6期

页      面：2481-2484页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：research funding from Guangzhou Women and Children Medical Center,the National Key Research and Development Program of China(2018YFA0107200) National Natural Science Foundation of China(81730005 and 31771616) Macao FDCT(FDCT 0106/2021/A)。 

主　　题：immunity vaccine pattern 

摘      要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped positive-sense single-stranded RNA(ssRNA)virus responsible for the global COVID-19 pandemic.Although vaccines for SARS-CoV-2 have been developed and applied worldwide,research on vaccine adjuvant is lacking.Viral infections normally elicit a range of innate immune responses through the activation of pattern recognition receptors(PRRs).