Ethanolic extract of Abrus precatorius leaves protected against mercury chloride-induced hepatocellular damage and cerebral Na+/K+-ATPase dysfunction in wistar rats
作者机构：Department of BiochemistryFaculty of Pure and Applied SciencesFederal University WukariTaraba State 670101Nigeria Department of Cocoa Research Institute of NigeriaIbadanOyo State 200261Nigeria
出 版 物：《Toxicology Advances》 (毒理学前沿)
年 卷 期：2023年第5卷第2期
页 面：8-13页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：ethanolic extract Abrus precatorius hepatic parameters lipid peroxidation Na^(+)/K^(+)-ATPase activity mercury chloride in vivo
摘 要：Plants are sources of medicinal compounds,and they play a crucial role in human health *** precatorius is one of the important medicinal plants that have been alleged for their medicinal *** research unraveled the pharmacological effect of ethanolic extract of Abrus precatorius on lipid peroxidation,liver parameters,and Na^(+)/K^(+)-ATPase activity in HgCl_(2) treated wistar ***-four(24)albino wistar rats weighing between 150-200 g were distributed into four groups of 6 animals *** A(control)received normal saline(0.9% NaCl),group B received 400 mg/kg of the extract only,group C received 4 mg/kg HgCl_(2) only,and group D received 400 mg/kg of extract+4 mg/kg of HgCl_(2).The treatment lasted for two weeks,and the animals were sacrificed on the 15th *** blood,brains and livers were collected and used for assay of lipid peroxidation,liver function,and sodium pump *** results of liver function test revealed an elevated(P0.05)level of serum aspartate transaminase,alanine transaminase,alkaline phosphatase,and total bilirubin in the group that received HgCl_(2) only(group C)when compared with the normal control(group A)that received normal saline ***,the administration of extract in group D led to a marked(P0.05)reduction in the activities of these enzymes and the level of total bilirubin when compared to the negative control(group C).On the contrary,HgCl_(2) caused a significant(P0.05)reduction in serum total protein and albumin levels,but the extract reversed the effect of HgCl_(2) by elevating their ***,the effect elicited by this extract is comparable to group A which received normal ***,the result of lipid peroxidation revealed that HgCl_(2) treatment caused a marked(P0.05)increase in the formation of lipid peroxidation adducts in both liver and brain homogenates in group *** the contrary,administration of Abrus precatorius extract profoundly(P0.05)inhibited HgCl_(2)-
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