Synthesis of spirocyclopropylpyrazole derivatives via the cascade reaction of alkylidenecyclopropanes with pyrazolidinones and trifluoroethanol

作     者：Mengyang Shen Yuanshuang Xu Xinying Zhang Xuesen Fan 

作者机构：NMPA Key Laboratory for Research and Evaluation of Innovative DrugCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第5期

页      面：1410-1416页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：We are grateful to the National Natural Science Foundation of China(U2004189) the Central Plains Science and Technology Innovation Leader Project(224200510009) the Program for Innovative Research Team in Science and Technology in Universities of Henan Province(20IRTSTHN005) the Natural Science Foundation of Henan Province(212300410364) the Henan Key Laboratory of Organic Functional Molecules and Drug Innovation the 111 Project(D17007)for financial support. 

主　　题：alkyl ethanol spiro 

摘      要：A novel synthesis of spirocyclopropylpyrazole derivatives tethered with a trifluoromethyl unit through an unprecedented cascade reaction of alkylidenecyclopropanes with pyrazolidinones and trifluoroethanol(TFE)has been developed.