A network pharmacology-based investigation of the mechanism of action of chrysanthemum in treating dry eye
作者机构：College of traditional Chinese MedicineHunan University of Chinese MedicineChangsha 410208China Ophthalmology of Traditional Chinese Medicinethe First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410007China
出 版 物：《TMR Pharmacology Research》 (TMR药理学研究)
年 卷 期：2023年第3卷第2期
页 面：25-29页
学科分类：08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）]
基 金：This study was supported by the following grants:National Natural Science Foundation of China General Program funded projects(30772824,81574031) Hunan Provincial Key Laboratory Construction Project for Traditional Chinese Medicine Prevention and Treatment of Ophthalmic Diseases(2017TP1018) Key Discipline Construction Project of Traditional Chinese Medicine Ophthalmology from State Administration of Traditional Chinese Medicine(ZK 1801YK015) Changsha Science and Technology Plan Projects(K1501014-31,KC1704005) Hunan Provincial Graduate Research and Innovation Projects(CX20220780) Research Innovation Projects for Graduate Students at Hunan University of Chinese Medicine(2022YF01)
主 题：chrysanthemum dry eye network pharmacology traditional Chinese medicine targets signaling pathway
摘 要：Background:Dry eye is a chronic inflammatory disease of the ocular surface that is caused by multiple factors,characterized by pain,visual disturbance,and ocular *** is a common ophthalmic disease worldwide and a hot research field for scholars both domestically and *** article employs network pharmacology methods to analyze the mechanism of Chrysanthemum in treating dry eye,which is a promising ***:The TCMSP(http://***/***)was used to screen for candidate active ingredient molecules of chrysanthemum with oral bioavailability≥30%and drug similarity to chrysanthemum≥0.18 as *** active ingredients of chrysanthemum were searched using the“Related Targetscolumn in the TCMSP,followed by target ***,Cytoscape 3.6.0 was employed to construct a compound-target network for *** Online Mendelian Inheritance in Man and DisGeNET databases were used to identify pathogenic genes associated with dry ***,the STRING database was used to construct an interaction network and bar graph of intersecting target proteins in chrysanthemum to analyze protein interactions and core *** obtain key targets of active ingredients of chrysanthemum for treating dry eye,active ingredients targets of chrysanthemum and dry eye targets were intersected using ***,a drug-active ingredient-key target-disease network was *** Ontology functional annotation of key targets was performed using the WEBGESTALT database,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment was performed using the REACTOM ***:Eighty active ingredients of chrysanthemum corresponding to targets were *** active ingredients,508 predicted targets were identified,along with 4180 genes associated with dry eye and 45 key targets of chrysanthemum for treating dry *** functions of key targets primarily include regulation of gene expression,oxidative stress,immune response,
维普期刊数据库