Roles and implications of mRNA N^(6)-methyladenosine in cancer
作者机构：Department of Experimental ResearchSun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Collaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsuP.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2023年第43卷第7期
页 面：729-748页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key R&D Program of China(2021YFA1302100) Natural Science Foundation of China(82072617 to J.Zheng,82003162 to J.Zhang) Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S096 to D.L.) Sun Yat-sen University Intramural Funds(to D.L.and to J.Zheng)
主 题：cancer therapy immunotherapy m^(6)A methylation N^(6)-methyladenosine
摘 要：RNA N^(6)-methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics,garnering increased *** date,m^(6)A modification has been shown to impact multiple RNA metabolic processes and play a vital role in numerous biological *** evidence suggests that aberrant m^(6)A modification is a hallmark of cancer,and it plays a critical role in cancer development and progression through multiple ***,we review the biological functions of mRNA m^(6)A modification in various types of cancers,with a particular focus on metabolic reprogramming,programmed cell death and tumor ***,we discuss the potential of targetingm^(6)Amodification or its regulatory proteins as a novel approach of cancer therapy and the progress of research on m^(6)A modification in tumor immunity and ***,we summarize the development of different m^(6)A detection methods and their advantages and disadvantages.
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