Synergistic catalysis for stereocontrol of prochiral nucleophiles in palladium-catalyzed asymmetric allylic substitution

作     者：Xi Wang Youbin Peng Ling Zhao Xiaohong Huo Wanbin Zhang 

作者机构：Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsFrontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第8期

页      面：2238-2255页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 0806[工学-冶金工程] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(21831005,21991112,22171183) the Science and Technology Commission of Shanghai Municipality(19JC1430100) 

主　　题：asymmetric allylic substitution palladium catalysis synergistic catalysis remote stereocontrol bimetallic catalysis 

摘      要：In contrast to the stereocontrol of the stereocenter at the allyl unit,the asymmetric induction of prochiral nucleophiles remains a challenge in Pd-catalyzed asymmetric allylic substitutions due to the remote distance between the chiral catalyst and the stereocenter established at prochiral *** effort has been devoted to solving this challenge through the elaborate design of chiral ***,synergistic catalysis has gained increasing attention owing to its potential advantages over the traditional single palladium catalysis,such as improvement of reactivity and *** strategy,including bimetallic catalysis and Pd/organocatalysis,not only broadens the scope of prochiral nucleophiles,but also provides a simple and unified method for the stereocontrol of prochiral *** review summarizes the brief history and advances in this field.