Palladium-catalyzed alkynylative[5+1]carboannulation of 1,3-diarylprop-2-yn-1-yl acetates with terminal alkynes enabled by C-H functionalization

作     者：Jiang-Xi Yu Li-Jun Wu Zhi-Qiang Wang Zhi-Feng Xu Jin-Heng Li 

作者机构：Key Laboratory of Functional Meta-Organic Compounds of Hunan ProvinceKey Laboratory of Functional Organometallic Materials(University of Hunan Province)Hengyang Normal UniversityHengyang 421008China College of SciencesCentral South University of Forestry and TechnologyChangsha410004China Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources RecycleNanchang Hangkong UniversityNanchang 330063China School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 475004China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第5期

页      面：1389-1394页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：We thank the National Natural Science Foundation of China(No.21625203 and 21871126) the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2021ZD01)for financial support. 

主　　题：catalyzed Palladium palladium 

摘      要：A new method for the synthesis of 3-ethynyl-1-methylene-1,2-dihydronaphthalenes via copper-pro-moted palladium-catalyzed intermolecular alkynylative[5+1]carboannulation of 1-arylphenyl-prop-2-yn-1-yl acetates involving C–H functionalization is described.Two terminal alkyne molecules serve as an alkynylation reagent and a one-carbon unit to enable alkynylative[5+1]carboannulation with excellent selectivity control,broad substrate scope and good tolerance of functional groups.