A histone tale that enCOMPASSes pausing:new insights into the functional repertoire of H3K4me3

作     者：Thomas K.Albert Kornelius Kerl Thomas K.Albert;Kornelius Kerl

作者机构：Department of Pediatric Hematology and OncologyUniversity Children’s Hospital MuensterMuensterGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第8期

页      面：3555-3557页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：This work was supported by grants from the Kinderkrebshilfe Muenster the Deutsche Krebshilfe the Deutsche Kinderkrebsstiftung and the Deutsche Forschungsgemeinschaft to K.K 

主　　题：involvement functional insight 

摘      要：A recently published study in Nature provides compelling evidence for the involvement of the histone H3K4me3 modification in regulating RNA polymerase II(Pol II)pause-release and elongation.1 The expansion of the functional repertoire of this active chromatin mark and the elucidation of the molecular mechanisms behind it represents a major advance for the field,not least because the epigenetic factors involved are linked to a wide range of human *** term epigenetics derives from the Greek prefix“epiand describes an inheritable regulatory state that manifests itself beyond the mere genetic information encoded in the DNA.