Vitamin E in the management of pancreatic cancer: A scoping review
作者机构：Department of PharmacologyFaculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia Faculty of Applied SciencesUCSI UniversityKuala Lumpur 56000Malaysia Newcastle University Medicine MalaysiaIskandar Puteri 79200JohorMalaysia State Key Laboratory of Oncogenes and Related GenesRenji-Med X Clinical Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Pharmaceutical ChemistryFaculty of Pharmaceutical SciencesUCSI UniversityKuala Lumpur 56000Malaysia
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第6期
页 面：943-958页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Science and Technology Commission of Shanghai Municipality STCSM (20WZ2504600)
主 题：Anti-cancer treatment Pancreatic cancer Scoping review Tocopherol Tocotrienol Vitamin E
摘 要：Pancreatic cancer is the leading cause of cancer mortality *** investigating effective management strategies for pancreatic cancer is *** E,consisting of both tocopherol and tocotrienol,has demonstrated debatable effects on pancreatic cancer ***,this scoping review aims to summarize the effects of vitamin E on pancreatic *** October 2022,a literature search was conducted using PubMed and Scopus since their *** studies on the effects of vitamin E on pancreatic cancer,including cell cultures,animal models and human clinical trials,were considered for this *** literature search found 75 articles on this topic,but only 24 articles met the inclusion *** available evidence showed that vitamin E modulated proliferation,cell death,angiogenesis,metastasis and inflammation in pancreatic cancer ***,the safety and bioavailability concerns remain to be answered with more extensive preclinical and clinical *** in-depth analysis is necessary to investigate further the role of vitamin E in the management of pancreatic cancers.
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