Panniculitis,an Uncommon Skin Manifestation in Adult Dermatomyositis

作     者：Xiao-Jing Xing Song Wang An-Qi Li Zi-Hang Li Bi-Wen Lin Xiao-Jing Xing;Song Wang;An-Qi Li;Zi-Hang Li;Bi-Wen Lin

作者机构：Department of DermatologyBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of RadiologyFirst Medical Center of PLA General HospitalBeijing 100853China Department of DermatologyFirst Medical Center of Chinese PLA General HospitalBeijing 100853China 

出 版 物：《International Journal of Dermatology and Venereology》 (国际皮肤性病学杂志（英文）)

年 卷 期：2023年第6卷第2期

页      面：96-101页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：adult dermatomyositis myositis-specific antibodies panniculitis anti-NXP2 antibody calcinosis 

摘      要：Objective:The skin manifestations of dermatomyositis(DM)are complex and diverse,with some rashes having diagnostic significance,while others have a certain suggestive effect on the patient’s condition,visceral damage,and prognosis.This case-cohort study was performed to investigate the skin manifestations of 205 adult inpatients with DM.We then analyzed the association between the clinical characteristics and panniculitis in adult patients with DM.Methods:This study was conducted at the First Medical Center of PLA General Hospital,Beijing,China from March 1,2016 to December 30,2020 with follow-up until December 31,2021.This case-cohort study involved 205 eligible participants with DM who met the criteria for idiopathic inflammatory myopathy.Clinical data,cutaneous manifestations,and lesion locations were screened and analyzed.Serum samples were collected,and immunoblotting was used to detect 16 types of myositis-specific antibodies and myositis-associated antibodies.Results:The results showed that 16(7.8%)of the 205 adult patients with DM had panniculitis.The panniculitis was mainly distributed in the subcutaneous fat of the abdomen,buttocks,and thighs.This condition was often accompanied by skin ulcers,atrophic scars,and calcinosis.Moreover,9(72.7%)of the 16 patients with panniculitis were positive for antibodies to nuclear matrix protein 2(anti-NXP2 antibodies).Conclusion:The data showed that panniculitis is an uncommon skin manifestation in adult patients with DM,with a positivity rate of 7.8%.The appearance of panniculitis is likely associated with anti-NXP2 antibodies.