Phylogenomic discovery of deleterious mutants completes the potato breeding revolution

作     者：Alisdair R.Fernie Saleh Alseekh Alisdair R.Fernie;Saleh Alseekh

作者机构：Max-Planck-lnstitute of Molecular Plant PhysiologyAm Muhlenberg 114476 Potsdam-GolmGermany Center for Plant Systems Biology and Biotechnology4000 PlovdivBulgaria 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2023年第16卷第7期

页      面：1103-1105页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 

主　　题：breeding fertility collective 

摘      要：After many decades of attempts,recent years have finally witnessed the reinvention of potato from a clonally propagated autotetraploid to a seed-propagated inbred line-based diploid hybrid(Zhang et al.,2021).This can be anticipated to accelerate potato breeding from a cumbersome,non-accumulative mode to a rapid iterative one(Wu et al.,2023).That said,a major hurdle in achieving this is the fact that the clonally propagated potato has amassed a huge number of deleterious mutations(Zhang et al.,2019).These mutations are at least partially masked in the heterozygous state,but their detrimental effects are exposed during the process of developing inbred lines,rendering this a considerable *** Zhang et al.(2021)previously developed two inbred lines,the first generation of highly homozygous inbred lines,these contained mutations that collectively resulted in negative fitness manifesting in frail growth,reduced fertility,and low *** a recent study,Wu et al.(2023)utilized genomic evolutionary rate profiling(GERP)analysis to identify and quantify deleterious mutations at the genome-wide scale.