Intrahepatic cholangiocarcinoma in patients with primary sclerosing cholangitis and ulcerative colitis: Two case reports

作     者：Takahiro Miyazu Natsuki Ishida Yusuke Asai Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Satoshi Baba Ken Sugimoto 

作者机构：First Department of MedicineHamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Endoscopic and Photodynamic MedicineHamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Laboratory MedicineHamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Diagnostic PathologyHamamatsu University School of MedicineHamamatsu 431-3192Japan 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第6期

页      面：1224-1231页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Ulcerative colitis Primary sclerosing cholangitis Intrahepatic cholangiocarcinoma Hepatic lobectomy Inflammatory bowel disease Case report 

摘      要：BACKGROUND Primary sclerosing cholangitis(PSC)is an extraintestinal manifestation of ulcerative colitis(UC).PSC is a well-known risk factor for intrahepatic cholangiocarcinoma(ICC),and ICC is known to have a poor *** SUMMARY We present two cases of ICC in patients with PSC associated with *** the first case,a tumor was found by magnetic resonance imaging(MRI)in the liver of a patient with PSC and UC who presented to our hospital with right-sided rib *** second patient was asymptomatic,but we unexpectedly detected two liver tumors in an MRI performed to evaluate bile duct stenosis associated with *** was strongly suspected by computed tomography and MRI in both cases,and surgery was performed,but unfortunately,the first patient died of ICC recurrence 16 mo postoperatively,and the second patient died of liver failure 14 mo *** Careful follow-up of patients with UC and PSC with imaging and blood tests is necessary for early detection of ICC.