Treatment of Candida albicans liver abscess complicated with COVID-19 after liver metastasis ablation:A case report

作     者：Wen Hu Xi Lin Meng Qian Tao-Ming Du Xi Lan 

作者机构：Department of OncologyChengdu Seventh People’s HospitalChengdu 610000Sichuan ProvinceChina Department of OncologyYanting County People’s HospitalMianyang 621600Sichuan ProvinceChina Department of RadiologyChengdu Seventh People’s HospitalChengdu 610000Sichuan ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第7期

页      面：1311-1316页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Fungal Liver abscess COVID-19 Liver metastasis ablation Pancreatic head cancer Case report 

摘      要：BACKGROUND Liver interventional surgery is a relatively safe and minimally invasive ***,for patients who have undergone Whipple surgery,the probability of developing a liver abscess after liver interventional surgery is very *** liver abscess has a high mortality rate,especially when complicated with malignant tumors,diabetes,coronavirus disease 2019(COVID-19)and other *** liver abscess is rare,and there are no guidelines or expert consensus on the course of antifungal *** SUMMARY A 54-year-old woman with pancreatic head cancer received albumin-bound paclitaxel in combination with gemcitabine chemotherapy after laparoscopic *** metastasis was found 1 mo after completion of 8 cycles of chemotherapy,followed by ablation of the liver *** half a month of liver metastasis ablation,the patient experienced fever after chemotherapy and was diagnosed with liver abscess complicated with COVID-19 by contrast-enhanced abdominal computed tomography and real-time polymerase chain reaction *** results of pus culture showed Candida albicans,which was sensitive to *** patient underwent percutaneous catheter drainage,antifungal therapy with fluconazole,and antiviral therapy with *** antifungal therapy,the patient showed a significant increase in liver enzyme levels and was discharged after liver protection *** fluconazole was continued for 1 wk outside the hospital,and fluconazole was used for a total of 5 *** patient recovered well and received 4 cycles of fluorouracil,leucovorin,oxaliplatin,and irinotecan after 2 mo of antifungal *** Effective treatment of Candida albicans liver abscess requires early detection,percutaneous catheter drainage,and 5 wk of antifungal ***,complications such as COVID-19 should be actively managed and nutritional support should be provided.