Binary Bacillus subtilis protects the intestinal mucosa barrier and alleviates nonalcoholic steatohepatitis

作     者：Donglin Liu Pengguo Chen Donglin Liu;Pengguo Chen

作者机构：Department of GastroenterologyJiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxiChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2024年第7卷第3期

页      面：362-366页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funding support from the Natural Science Foundation of Jiangxi Province(20171BAB205011 20202BABL206014) 

主　　题：non alcoholic steatohepatitis 

摘      要：Background:Nonalcoholic steatohepatitis(NASH)is characterized by liver steatosis,inflammation,and even *** is likely to develop into cirrhosis and liver cancer,the major causes of liver related *** aimed to study the effect of probiotics on NASH via the gut-l iver ***:Thirty male Sprague-Dawley rats were divided into three groups.A control group of 10 rats was fed on a standard chow for 16 *** rats fed on a high-fat diet for 8 weeks were separated to two groups:a model group(10 rats)fed on vehicle for 8 weeks and a treatment group(10 rats)supplemented with binary Bacillus subtilis for 8 *** expression of IL-6 and TNF-ɑand ileum expression of IL-17 and occludin were ***:The high-fat diet caused inflammation of the liver and ileum in *** Bacillus subtilis treatment reduces liver inflammation through the intestinal liver *** levels of IL-6 and TNF-αwere detected in rats fed a high-fat diet,which were reduced to lower levels after treatment with binary Bacillus *** rats on the high-fat diet,elevated IL-17 levels and decreased occludin levels were *** with Bacillus subtilis reduced IL-17 levels and restored the expression of ***:Binary Bacillus subtilis has a beneficial effect on liver inflammation and intestinal damage.