2-Pyridinylmethyl borrowing:base-promoted C-alkylation of(pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp^(3))-C(sp^(3))bonds

作     者：Chuan-Ming Hong Fei-Fei Zou Xin Zhuang Zhen Luo Zheng-Qiang Liu Li-Qing Ren Qing-Hua Li Tang-Lin Liu 

作者机构：School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第2期

页      面：299-304页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support provided by the National Natural Science Foundation of China(21801209 and 21801210) the Fundamental Research Funds for the Central Universities(SWU118117,SWU118028 and XDJK2019AA003) the Venture&Innovation Support Program for Chongqing Overseas Returnees(cx2018085) the Natural Science Foundation of Chongqing,China(cstc2020jcyj-msxmX0130). 

主　　题：alcohols bonds cleavage 

摘      要：A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones,using(pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy,has been disclosed.This approach provides an efficient,available and environmentally benign access,leading to alkylation products with broad functional group tolerance and excellent yields.Meanwhile,the selective cleavage of unactivated C(sp^(3))-C(sp^(3))bonds of common secondary alcohols was achieved with high atom economy.