Circulating miR-548c-3p possesses good diagnostic potential for metabolic syndrome

作     者：Abdullahi Dandare Afrose Liaquat Muhammad Rafiq Mbah Ntepe Leonel Javeres Sidra Younis Muhammad Jawad Khan Abdullahi Dandare;Afrose Liaquat;Muhammad Rafiq;Mbah Ntepe Leonel Javeres;Sidra Younis;Muhammad Jawad Khan

作者机构：Department of BiosciencesCOMSATS University IslamabadIslamabad 45550Pakistan Department of BiochemistryUsmanu Danfodiyo University SokotoSokoto PMB 2346Nigeria Department of BiochemistryShifa College of MedicineShifa Tameer-E-Millat UniversityIslamabad 45550Pakistan Institute of Medical Research and Medical Plant StudiesMinistry of Scientific ResearchYaoindeCameroon Department of Biological SciencesNational University of Medical SciencesRawalpindiPunjab 46000Pakistan 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：683-686页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：COMSATS University Islamabad and Shifa Tameer-E-Millat University Islamabad Pakistan 

主　　题：JAK/STAT involvement diseases 

摘      要：Studies have shown that dysregulated expression of miRNAs is a major underlying event in the onset and progression of many metabolic diseases.The pathological role of miR-548c-3p in various cancer types,including breast cancer,glioma,prostate cancer,and gastric cancer,has been documented.1 However,experimental evidences validating the role of miR-548c-3p in the development of metabolic diseases are still lacking,and no data is available on its diagnostic potential for metabolic syndrome(MS).Recently,we predicted the involvement of miR-548c-3p in the pathogenesis of MS and its progression to cardiovascular diseases(CVD)via the regulation of target genes necessary for the proper function of insulin resistance,mTOR,and JAK/STAT signaling pathways.2 Therefore,we deemed it necessary to engage in wet laboratory analysis and validate these claims in patients with metabolic syndrome compared to healthy individuals.