Latent Space Representational Learning of Deep Features for Acute Lymphoblastic Leukemia Diagnosis

作     者：Ghada Emam Atteia 

作者机构：Information Technology DepartmentCollege of Computer&Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11461Saudi Arabia 

出 版 物：《Computer Systems Science & Engineering》 (计算机系统科学与工程（英文）)

年 卷 期：2023年第45卷第4期

页      面：361-376页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 0401[教育学-教育学] 1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：Autoencoder deep learning CNN leukemia diagnosis computeraided diagnosis 

摘      要：Acute Lymphoblastic Leukemia(ALL)is a fatal malignancy that is featured by the abnormal increase of immature lymphocytes in blood or bone marrow.Early prognosis of ALL is indispensable for the effectual remediation of this disease.Initial screening of ALL is conducted through manual examination of stained blood smear microscopic images,a process which is time-consuming and prone to errors.Therefore,many deep learning-based computer-aided diagnosis(CAD)systems have been established to automatically diagnose ALL.This paper proposes a novel hybrid deep learning system for ALL diagnosis in blood smear images.The introduced system integrates the proficiency of autoencoder networks in feature representational learning in latent space with the superior feature extraction capability of standard pretrained convolutional neural networks(CNNs)to identify the existence of ALL in blood smears.An augmented set of deep image features are formed from the features extracted by GoogleNet and Inception-v3 CNNs from a hybrid dataset of microscopic blood smear images.A sparse autoencoder network is designed to create an abstract set of significant latent features from the enlarged image feature set.The latent features are used to perform image classification using Support Vector Machine(SVM)classifier.The obtained results show that the latent features improve the classification performance of the proposed ALL diagnosis system over the original image features.Moreover,the classification performance of the system with various sizes of the latent feature set is evaluated.The retrieved results reveal that the introduced ALL diagnosis system superiorly compete the state of the art.