Catalytic enantioselective domino alkenylation-alkynylation of alkenes: stereoselective synthesis of 5–7 membered azacycles and carbocycles

作     者：Zhaoming Ma Lantian Sun Jianrong Steve Zhou Zhaoming Ma;Lantian Sun;Jianrong Steve Zhou

作者机构：State Key Laboratory of Chemical OncogenomicsGuangdong Provincial Key Laboratory of Chemical GenomicsSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Department of ChemistryHong Kong Baptist UniversityHong KongChina 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第6期

页      面：1701-1706页

核心收录：

学科分类：081704[工学-应用化学] 081705[工学-工业催化] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(22271007) the Peking University Shenzhen Graduate School the State Key Laboratory of Chemical Oncogenomics the Guangdong Provincial Key Laboratory of Chemical Genomics the Shenzhen Bay Laboratory and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs for JSZ 

主　　题：membered cycles synthesis 

摘      要：Enantioselective domino alkenylation-alkynylation of olefins is achieved for the first time,using terminal alkynes directly as *** new reaction enables facile construction of azacycles carrying quaternary stereocenters,including 5–7 membered pyrrolidines,piperidines and ***,alkynyl groups in azacyclic products provide a useful handle for derivatization that formed both fused and bridged azabicycles.