Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
作者机构：Shanghai Diabetes InstituteDepartment of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China School of KinesiologyShanghai University of SportShanghai 200438China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第3期
页 面：825-847页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学]
基 金：supported by the National Key R&D Program of China(No.2018YFA0800600) National Natural Science Foundation of China(No.81770797) National Science Fund for Excellent Young Scholars(No.31722028) Training Program of the Major Research Plan of the National Natural Science Foundation(No.91857111) Shanghai Municipal Commission of Science and Technology(No.20410713200) National Facility for Translational Medicine(Shanghai)(NO.TMSK-2020-102) Shanghai Municipal Education Commission(No.20SG10) Shanghai University of Sports and National Science Fund for Excellent Young Scholars(No.31722028).
主 题：FGF21 Hepatokine Liver-adipose tissue crosstalk Obesity Therapeutic strategy
摘 要：Due to excess energy intake and a sedentary lifestyle, the prevalence of obesity is rising steadily and has emerged as a global public health problem. Adipose tissue undergoes structural remodeling and dysfunction in the obese state. Secreted proteins derived from the liver, also termed as hepatokines, exert multiple effects on adipose tissue remodeling and the development of obesity, and has drawn extensive attention for their therapeutic potential in the treatment of obesity and related diseases. Several novel hepatokines and their functions on systemic metabolism have been interrogated recently as well. The drug development programs targeting hepatokines also have shown inspiring benefits in obesity treatment. In this review, we outline how adipose tissue changes during obesity. Then, we summarize and critically analyze the novel findings on the effects of metabolic “beneficial and metabolic “harmful hepatokines to adipose tissue. We also discuss the in-depth molecular mechanism that hepatokines may mediate the liver-adipose tissue crosstalk, the novel technologies targeting hepatokines and their receptors in vivo to explore their functions, and the potential application of these interventions in clinical practice.
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