A revision of the InfiniumPurify R package for genome-wide correction of tumor purity in Infinium DNA methylation array data

作     者：Phuc H.Hoang Phuc H.Hoang

作者机构：Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaMD 20892USA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：698-700页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the Intramural Research Program Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health USA. 

主　　题：alterations purity correction 

摘      要：Understanding DNA methylation(DNAm)alterations in tumors is important to develop novel therapeutic targets and powerful biomarkers,and to gain insights into tumorigenesis processes.As many studies have highlighted the confounding effects of tumor purity in DNAm analyses,1,2,3 various tools have also been developed to tackle the issue.2,3,4 Among them,InfiniumPurify R package is a popular and widely cited tool,2,3,5 consisting of a set of statistical methods to estimate and account for tumor purity in cancer DNAm analyses.