Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
作者机构：Department of Neurophysiology and NeuropharmacologyInstitute of Special Environmental Medicine and Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu 226019China Biological SciencesFaculty of Environmental and Life SciencesUniversity of SouthamptonSouthamptonSO171BJUnited Kingdom Institute for Life SciencesUniversity of SouthamptonSouthamptonSO171BJUnited Kingdom
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第3期
页 面：1029-1039页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：supported by Natural Science Research of Jiangsu Higher Education Institutions of China(No.19KJB320002) the Science and Technology Project of Nantong City China(No.JC2020010) a Research Startup Fund of Nantong University Yihua Wang was supported by the UK Medical Research Council(No.MR/S025480/1) the UK Royal Society(No.IEC/NSFC/191030) Zhenglin Jiang was supported by the National Natural Science Foundation of China(No.82171869 and 81671859) Xia Li was supported by the Science and Technology Project of Nantong City China(No.MS12020019 and JC2021079).
主 题：Epithelial-mesenchymal transition Hyperbaricoxygen Hypoxia Pulmonary fibrosis Systematic analysis
摘 要：Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.
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