Postbiotics as potential new therapeutic agents for sepsis
作者机构：Medical SchoolKunming University of Science and Technology727 Jingming South RoadChenggong DistrictKunming 650500China Department of Emergency MedicineThe First People’s Hospital of Yunnan Province157 Jinbi RoadXishan DistrictKunming 650034China
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2023年第11卷第1期
页 面：510-523页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：supported by the National Natural Science Foundation of China(No.82160366) Yunnan Young and Middle-aged Academic and Technical Leaders Reserve Talent Project(No.C098-2060499) Yunnan Clinical Medical Center Open Project(No.2021LCZXXF-HX03) Yunnan Key Laboratory of Stomatology Open Project(No.2022YNKQ004)
主 题：Sepsis Gut microbiota Dysbiosis Postbiotics
摘 要：Sepsis is the main cause of death in critically ill patients and gut microbiota dysbiosis plays a crucial role in *** the one hand,sepsis leads to the destruction of gut microbiota and induces and aggravates terminal organ *** the other hand,the activation of pathogenic gut flora and the reduction in beneficial microbial products increase the susceptibility of the host to *** probiotics or fecal microbiota transplantation preserve gut barrier function on multiple levels,their efficacy in sepsis with intestinal microbiota disruptions remains *** consist of inactivated microbial cells or cell *** possess antimicrobial,immunomodulatory,antioxidant and antiproliferative ***-targeted therapy strategies,such as postbiotics,may reduce the incidence of sepsis and improve the prognosis of patients with sepsis by regulating gut microbial metabolites,improving intestinal barrier integrity and changing the composition of the gut *** offer a variety of mechanisms and might even be superior to more conventional‘biotics’such as probiotics and *** this review,we present an overview of the concept of postbiotics and summarize what is currently known about postbiotics and their prospective utility in sepsis ***,postbiotics show promise as a viable adjunctive therapy option for sepsis.
维普期刊数据库