Heterogeneity in susceptibility to polycystic ovary syndrome among women with epilepsy
作者机构：Department of NeurologyJoint Research Institution of Altitude HealthWest China HospitalSichuan UniversityNo.37 Guo Xue XiangChengduSichuan 610041PR China
出 版 物：《Acta Epileptologica》 (癫痫学报（英文）)
年 卷 期：2023年第6卷第2期
页 面：100-106页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：Epilepsy Polycystic ovary syndrome Gene Impaired metabolism
摘 要：Background Epilepsy comorbidities adversely affect the quality of life of *** with epilepsy are at a high risk of comorbid endocrine *** them,the polycystic ovary syndrome(PCOS)has a threefold higher prevalence in women with epilepsy than in healthy women and is the main cause of infertility among the ***,women with epilepsy show heterogeneity in the susceptibility to *** heterogeneity may be associated with genetic *** To test this,we retrospectively collected clinical data from 45 female patients with epilepsy and divided them into three groups according to their susceptibility to *** A and B represented a high susceptibility to *** in Group A were diagnosed with PCOS before their first seizure,while patients in Group B were diagnosed with PCOS after a short period of monotherapy with a low dose of antiseizure medication(ASM)following the diagnosis of *** in Group C did not develop PCOS despite a prolonged treatment with high-dose *** compared the clinical data and genetic profiles among the three *** We found a clear trend of impaired metabolism in Group B patients and this may be associated with highfrequency mutations in MYO10 and *** Our study suggests that women with epilepsy are heterogeneous in the susceptibility to PCOS and this is associated with mutations in specific ***,genetic screening should be conducted to screen for women with epilepsy who are more likely to have comorbid PCOS,so that they can receive targeted interventions at an early stage to reduce the risk.
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