Targeting Microglia with Adeno-associated Viruses

作     者：Jing Sun Yufei Zheng Ji Hu 

作者机构：School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第5期

页      面：863-865页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：diseases Alzheimer immune 

摘      要：Microglia,the innate immune cells of the central nervous system(CNS),account for~10%of the total population in the CNS.They are one of the key regulators of the CNS under normal and pathological conditions,coordinating immune responses,and dynamically shaping neural circuits[1].Human genetic studies have found that most risk genes for neurodegenerative diseases,including Alzheimer s disease and Parkinson s disease,are specifically and strongly expressed in microglia[2].Given the vital role microglia play in the development of neurodegeneration,effective measures to label and manipulate them have become critical for the research community.