Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
作者机构：Department of PsychiatryWuhan Mental Health CenterWuhan 430012China Co-Innovation Center of NeurodegenerationNantong UniversityNantong 226001China Department of PathophysiologySchool of Basic MedicineKey Laboratory of Education Ministry/Hubei Province of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Wuhan Hospital for PsychotherapyWuhan 430012China Shenzhen Huazhong University of Science and Technology Research InstituteShenzhen 518000China.
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2022年第11卷第1期
页 面：461-473页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学]
基 金：grants from National Natural Science Foundation of China(31929002,92049107 and 81801077) Innovative Research Groups of the National Natural Science Foundation of China(81721005) Youth Program of Wuhan Municipal Health Commission Foundation(WX18Q41) Technology and Innovation Commission of Shenzhen Municipality(JCYJ20210324141405014) Guangdong Basic and Applied Basic Research Foundation(2020B1515120017)and the Academic Frontier Youth Team Project to Xiaochuan Wang from Huazhong University of Science and Technology.
主 题：Mitophagy Alzheimer’s disease PINK1 Tau Aβ
摘 要：Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration,including Alzheimer’s disease(AD).A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development.The interaction between mitophagy deficits and Aβor Tau pathology may form a vicious cycle and cause neuronal damage and death.Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD.Defective mitophagy is a potential target for AD prevention and treatment.
维普期刊数据库