Reprograming yeast for anti-cancer vinblastine synthesis
作者机构：CAS Key Laboratory of Quantitative Engineering BiologyShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China State Key Laboratory of Microbial MetabolismJoint International Research Laboratory of Metabolic&Developmental Sciencesand School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of Combinatorial Biosynthesis and Drug DiscoveryMinistry of EducationZhongnan Hospitaland School of Pharmaceutical SciencesWuhan UniversityWuhanHubei 430072China
出 版 物：《Life Metabolism》 (生命（代谢（英文）)
年 卷 期：2022年第1卷第3期
页 面：207-208页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：synthesis programming alkaloids
摘 要：In a recent study published in Nature,Zhang et *** an innovative approach by reprogramming and engineering yeast strain for combined biosynthesis of vindoline and catharanthine,followed by an additional in vitro chemical step for the successful synthesis of the anti-cancer *** and utilization of plant resources have played indispensable roles in the treatment of human diseases,which had been an amazing focus of biomedical research for *** indole alkaloids(MIAs),the plant secondary metabolites that mainly exist in Gentianales,had been a popular family of the medicinal drug research because of their remarkable structural diversities and biological activities.
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