Neuroimaging perspective in targeted treatment for type 2 diabetes melitus and sleep disorders

作     者：Karen M.von Deneen Malgorzata A.Garstka Karen M. von Deneen;Malgorzata A. Garstka

作者机构：Center for Brain ImagingSchool of Life Science and TechnologyXidian UniversityXi’anShaanxi 710126China International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment&Xi’an Key Laboratory of Intelligent Sensing and Regulation of trans-Scale Life InformationSchool of Life Science and TechnologyXidian UniversityXi’anShaanxi 710126China Core Research LaboratoryDepartment of Endocrinologythe Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Tumor and ImmunologyPrecision Medical InstituteWestern China Science and Technology Innovation PortSchool of Medicinethe Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China 

出 版 物：《Intelligent Medicine》 (智慧医学（英文）)

年 卷 期：2022年第2卷第4期

页      面：209-220页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This article is funded by the National Natural Science Foundation of China(Grant No.82172023) a Personal Fellowship(Grant No.87679215) Start-Up Budget(Grant No.82668428). 

主　　题：Neuroimaging Diabetes mellitus Sleep disorders Alternative medicine Electroacupuncture Hypothalamic-pituitary-adrenal axis 

摘      要：Type 2 diabetes mellitus(T2DM)and sleep disorders(SD)have become important and costly health issues world-wide,particularly in China.Both are common diseases related to brain functional and structural abnormalities involving the hypothalamic-pituitary-adrenal(HPA)axis.The brains of individuals who suffer from both diseases simultaneously might be different compared to healthy individuals.This review assessed current neuroimaging findings to develop alternative targeted treatments for T2DM and SD.Relevant articles published between Jan-uary 2002 and September 2021 were searched in PubMed and Web of Science databases.Generalized treatment methods for T2DM include dietary/weight-loss management,metformin or a combination of two non-insulin drugs,and melatonin for SD,though alternative therapies including electroacupuncture(EA)have been utilized in treating both of these diseases separately because they are convenient,affordable,and safe.Standard and al-ternative treatments for T2DM were somehow effective in treating SD.Neuroimaging studies of these disorders can achieve higher treatment efficacy by targeting brain areas,such as the hypothalamus(HYP),as visualized via diffusion tensor imaging(DTI),and functional magnetic resonance imaging(fMRI).DTI and fMRI can map the human brain and are utilized in many experiments.Thus,we propose that neuroimaging studies could be used in treatment of SD in T2DM.