An atlas of glucose uptake across the entire human body as measured by the total-body PET/CT scanner:a pilot study

作     者：Weizhao Lu Zhaoping Cheng Xue Xie Kun Li Yanhua Duan Min Li Chao Ma Sijin Liu Jianfeng Qiu 

作者机构：Department of RadiologyShandong First Medical University&Shandong Academy of Medical SciencesTaianShandong 271016China Department of PET/CTthe First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan Hospital Affiliated to Shandong UniversityJinanShandong 250014China Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250100China State Key Laboratory of Environment Chemistry and EcotoxicologyResearch Center for Eco-Environment SciencesChinese Academy of SciencesBeijing 100085China 

出 版 物：《Life Metabolism》 (生命（代谢（英文）)

年 卷 期：2022年第1卷第2期

页      面：190-199页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the“Outstanding University Driven by Talents”Program and Academic Promotion Program of Shandong First Medical University(2020LJ002 and 2019QL009) the Taishan Scholars Program of Shandong Province(TS201712065) 

主　　题：glucose uptake PET/CT glucose uptake atlas uEXPLORER 

摘      要：Glucose uptake differs in organs and tissues across the human *** date,however,there has been no single atlas providing detailed glucose uptake profiles across the entire human ***,we aimed to generate a detailed profile of glucose uptake across the entire human body using the uEXPLORER positron emission tomography/computed tomography scanner,which offers the opportunity to collect glucose metabolic imaging quickly and simultaneously in all sites of the *** standardized uptake value normalized by lean body mass(SUL)of 18F-fluorodeoxyglucose was used as a measure of glucose *** developed a fingerprint of glucose uptake reflecting the mean SULs of major organs and parts across the entire human body in 15 healthy-weight and 18 overweight *** the segmentation of organs and body parts from the atlas,we uncovered the significant impacts of age,sex,and obesity on glucose uptake in organs and parts across the entire body.A difference was recognized between the right and left side of the ***,we generated a total-body glucose uptake atlas that could be used as the reference for the diagnosis and evaluation of disordered states involving dysregulated glucose metabolism.