A metabolic conspiracy drives anti-tumorigenic macrophages

作     者：Na Li Tiffany Horng Na Li;Tiffany Horng

作者机构：School of Life Sciences and TechnologyShanghaiTech UniversityShanghai 201210China 

出 版 物：《Life Metabolism》 (生命（代谢（英文）)

年 卷 期：2023年第2卷第2期

页      面：8-9页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：metabolism tumor activation 

摘      要：In the tumor microenvironment,activation of macrophages through CD40 ligation promotes tumor restriction and is being considered *** underpinning metabolic basis is not known and was addressed in a new study by Ho and *** activation(or polarization)to distinct cellular states—that are associated with the acquisition of new cellular activities—is fueled by metabolic *** such metabolic reprogramming can disrupt appropriate macrophage activation,thus there is increasing interest in targeting cellular metabolism to alter macrophage activities in a variety of pathophysiological settings[1].