Alzheimer’s Disease Stage Classification Using a Deep Transfer Learning and Sparse Auto Encoder Method

作     者：Deepthi K.Oommen J.Arunnehru 

作者机构：Department of Computer Science and EngineeringSRM Institute of Science and TechnologyVadapalaniChennai600026TamilnaduIndia 

出 版 物：《Computers, Materials & Continua》 (计算机、材料和连续体（英文）)

年 卷 期：2023年第76卷第7期

页      面：793-811页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：Alzheimer’s disease mild cognitive impairment Weiner filter contrast limited adaptive histogram equalization transfer learning sparse autoencoder deep neural network 

摘      要：Alzheimer’s Disease(AD)is a progressive neurological disease.Early diagnosis of this illness using conventional methods is very challenging.Deep Learning(DL)is one of the finest solutions for improving diagnostic procedures’performance and forecast accuracy.The disease’s widespread distribution and elevated mortality rate demonstrate its significance in the older-onset and younger-onset age groups.In light of research investigations,it is vital to consider age as one of the key criteria when choosing the subjects.The younger subjects are more susceptible to the perishable side than the older onset.The proposed investigation concentrated on the younger onset.The research used deep learning models and neuroimages to diagnose and categorize the disease at its early stages automatically.The proposed work is executed in three steps.The 3D input images must first undergo image pre-processing using Weiner filtering and Contrast Limited Adaptive Histogram Equalization(CLAHE)methods.The Transfer Learning(TL)models extract features,which are subsequently compressed using cascaded Auto Encoders(AE).The final phase entails using a Deep Neural Network(DNN)to classify the phases of AD.The model was trained and tested to classify the five stages of AD.The ensemble ResNet-18 and sparse autoencoder with DNN model achieved an accuracy of 98.54%.The method is compared to state-of-the-art approaches to validate its efficacy and performance.