Ori-Finder 2022:A Comprehensive Web Server for Prediction and Analysis of Bacterial Replication Origins

作     者：Mei-Jing Dong Hao Luo Feng Gao Mei-Jing Dong;Hao Luo;Feng Gao

作者机构：Department of PhysicsSchool of ScienceTianjin UniversityTianjin 300072China Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education)Tianjin UniversityTianjin 300072China SynBio Research PlatformCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin 300072China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2022年第20卷第6期

页      面：1207-1213页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Key R&D Program of China(Grant No.2018YFA0903700) the National Natural Science Foundation of China(Grant Nos.21621004 and 31571358) 

主　　题：Bacteria DNA replication Replication origin Z-curve DnaA-trio 

摘      要：The replication of DNA is a complex biological process that is essential for *** DNA replication is initiated at genomic loci referred to as replication origins(oriCs).Integrating the Z-curve method,DnaA box distribution,and comparative genomic analysis,we developed a web server to predict bacterial oriCs in 2008 called Ori-Finder,which is helpful to clarify the characteristics of bacterial *** oriCs of hundreds of sequenced bacterial genomes have been annotated in the genome reports using Ori-Finder and the predicted results have been deposited in DoriC,a manually curated database of *** has facilitated large-scale data mining of functional elements in oriCs and strand-biased ***,we describe Ori-Finder 2022 with updated prediction framework,interactive visualization module,new analysis module,and user-friendly *** species-specific indicator genes and functional elements of oriCs are integrated into the updated framework,which has also been redesigned to predict oriCs in draft *** interactive visualization module displays more genomic information related to oriCs and their functional *** analysis module includes regulatory protein annotation,repeat sequence discovery,homologous oriC search,and strand-biased *** redesigned interface provides additional customization options for oriC ***-Finder 2022 is freely available at http://***/Ori-Finder/and https://***/Ori-Finder/.