Size engineering of 2D MOF nanosheets for enhanced photodynamic antimicrobial therapy

作     者：Baoli Xue Xiwen Geng Haohao Cui Huiying Chen Zhikang Wu Hong Chen Hai Li Zhan Zhou Meiting Zhao Chaoliang Tan Jingguo Li Baoli Xue;Xiwen Geng;Haohao Cui;Huiying Chen;Zhikang Wu;Hong Chen;Hai Li;Zhan Zhou;Meiting Zhao;Chaoliang Tan;Jingguo Li

作者机构：Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003China College of Chemistry and Chemical EngineeringHenan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China Luoyang Key Laboratory of Organic Functional MoleculesCollege of Food and DrugLuoyang Normal UniversityLuoyang 471934China Institute of Advanced Materials(IAM)and Key Laboratory of Flexible Electronics(KLoFE)Nanjing Tech University(NanjingTech)Nanjing 211816China Department of ChemistryInstitute of Molecular Aggregation ScienceTianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityTianjin 300072China Department of Chemistry and Center of Super-Diamond and Advanced Films(COSDAF)City University of Hong KongHong Kong 999077China Shenzhen Research InstituteCity University of Hong KongShenzhen 518057China Pharmaceutical Sciences LaboratoryAbo Akademi UniversityTurku 20520Finland 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第9期

页      面：219-224页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：the funding support from the National Natural Science Foundation of China(No.52102348) the funding support from the National Natural Science Foundation of China(No.52173143) the funding support from the National Natural Science Foundation of China(No.22005259) the Science and Technology Innovation Talent Program of University in Henan Province(No.23HASTIT016) the funding support from China Postdoctoral Science Foundation(No.2021M701113) the Start-Up Grant(No.9610495)from City University of Hong Kong the funding support from the National Natural Science Foundation of China(No.21905195) Natural Science Foundation of Tianjin City(No.20JCYBJC00800) the PEIYANG Young Scholars Program of Tianjin University(No.2020XRX-0023) 

主　　题：2D nanosheets PCN-134 MOFs Size effect Photodynamic therapy Antibacterial 

摘      要：Although porphyrin-based metal-organic frameworks(MOFs)have been widely explored as photosensitizers for photodynamic therapy,how the size will affect the light-induced catalytic activity for generation of reactive oxygen species(ROS)still remain ***,we first report the size-controlled synthesis of two-dimensional(2D)porphyrin-based PCN-134 MOF nanosheets by a two-step solvothermal method to explore the size effect on its PDT performance,thus yielding enhanced photodynamic antimicrobial *** simply controlling the reaction temperature in the synthesis process,the bulk PCN-134 crystal,large PCN-134(L-PCN-134)nanosheets with a lateral size of 2–3μm and thickness of 33.2–37.5 nm and small PCN-134 nanosheets(S-PCN-134)with a lateral size of 160–180 nm and thickness of 9.1–9.7 nm were successfully ***,the S-PCN-134 nanosheets exhibit much higher photodynamic activity for ROS generation than that of the bulk 3D PCN-134 crystal and L-PCN-134 nanosheets under a660 nm laser irradiation,suggesting that the photodynamic activity of PCN-134 MOF increases when the size ***,the S-PCN-134 nanosheets show much enhanced performance when used as a photosensitizer for photodynamic antimicrobial activity and wound healing.