Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
作者机构：Department of Biological RepositoriesFrontier Science Center for Immunology and MetabolismMedical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan 430071China Human Genetics Resource Preservation Center of Wuhan UniversityWuhan 430071China
出 版 物：《Cell Regeneration》 (细胞再生（英文）)
年 卷 期：2022年第11卷第1期
页 面：227-245页
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(91740102) the Science and Technology Department of Hubei Province(2021CFA049) Health Commission of Hubei Province scientific research project(WJ2021Q029) the Fundamental Research Funds for the Central Universities in China(2042021kf0207).
主 题：Pancreaticβcell Human pluripotent stem cells Stepwise differentiation Diabetes mellitus
摘 要：Pancreaticβcells differentiated from stem cells provide promise for cell replacement therapy of diabetes.Human pluripotent stem cells could be differentiated into definitive endoderm,followed by pancreatic progenitors,and then subjected to endocrinal differentiation and maturation in a stepwise fashion.Many achievements have been made in making pancreaticβcells from human pluripotent stem cells in last two decades,and a couple of phase I/II clinical trials have just been initiated.Here,we overview the major progresses in differentiating pancreaticβcells from human pluripotent stem cells with the focus on recent technical advances in each differentiation stage,and briefly discuss the current limitations as well.
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