An integrated microfluidic device for the simultaneous detection of multiple antibiotics

作     者：Xiaorui Wang Gaowa Xing Nan Li Yaoshuang Xie Ling Lin Xiaorui Wang;Gaowa Xing;Nan Li;Yaoshuang Xie;Ling Lin

作者机构：Department of BioengineeringBeijing Technology and Business UniversityBeijing 100048China College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第8期

页      面：287-290页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083203[工学-农产品加工及贮藏工程] 

基　　金：This work was supported financially by the National Natural Science Foundation of China(Nos.82073816 and 21727814) Advanced Talents of Beijing Technology and Business University(No.19008021179) 

主　　题：Residual antibiotics Microfluidic chip Cruciform valves Point-of-care-testing(POCT) Simultaneous detection 

摘      要：Residual antibiotics in food pose a serious long-term threat to human ***,an on-site visualization method for antibiotic detection is ***,the requirements of traditional antibiotic testing methods in terms of operator proficiency and equipment cost hinder the rapid point-of-caretesting detection of suspected ***,we reported an integrated microfluidic device combining a microfluidic chip containing cruciform valves with immunochromatographic strips for the rapid detection of multiple antibiotics in *** rapid qualitative and quantitative analysis of four types of antibiotics(sulfonamides,β-lactams,streptomycin,and tetracyclines)was performed using mobile phone photography and mobile phone application *** detection time was maintained at 10 *** limits of detection(LODs)for the four antibiotics were 0.15,0.12,0.25,and 0.29 ng/mL,respectively,and the selectivity for the different antibiotics was observed even in a highly complex *** device successfully integrated separation and real-time detection onto a chip and might provide a promising perspective for the detection of multiple antibiotics in milk.