Flavidanolides A and B from Isodon flavidus

作     者：Jiang-Hai Ye Guo-Yong Luo Chen-Liang Zhao Zheng-Ming Liang Jin-Huai Wei Ya-Hua Liu Kang He Lu-Tai Pan Jing-Jie Zhang Juan Zou Hong-Jie Zhang Jiang-Hai Ye;Guo-Yong Luo;Chen-Liang Zhao;Zheng-Ming Liang;Jin-Huai Wei;Ya-Hua Liu;Kang He;Lu-Tai Pan;Jing-Jie Zhang;Juan Zou;Hong-Jie Zhang

作者机构：School of PharmacyGuizhou University of Traditional Chinese MedicineGuiyang 550025China School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China 

出 版 物：《中国化学快报:英文版》 (Chinese Chemical Letters)

年 卷 期：2023年第34卷第9期

页      面：160-164页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.82204605) the National Natural Science Foundation of China(No.81560709) the Technology Fund of Guizhou Administration of Traditional Chinese Medicine(No.QZYY-2022019) Science and Technology Tip-top Talent Foundation of Universities in Guizhou Province(No.Qian jiao he KY(2021)034) the Research Grant Council of the Hong Kong Special Administrative Region,China(No.HKBU 12102219) the University Grants Committee of the Hong Kong Special Administrative Region,China(UGC Research Matching Grant Scheme,No.RMG2019_1_19) 

主　　题：Isodon flavidus Rearranged six/seven/five-membered skeleton Heterodimeric diterpenoid Plausible biosynthetic pathway Antiinflammatory effects 

摘      要：A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A(1),a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton,together with flavidanolide B(2),an uncommon heterodimeric diterpenoid consisting of a norabietane and a seco-isopimarane monomeric *** structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction *** plausible biosynthetic routes were also *** the bioassay,flavidanolide B was found to exhibit good inhibitory effect against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in RAW264.7 cells comparable to positive control pyrrolidinedithiocarbamate ammonium(PDTC),which provided evidence for the medicinal value of *** as a folk medicine for treating inflammatory diseases.