Systematic review and meta-analysis: Comparing hepatocellular and cholestatic patterns of drug-induced liver injury
作者机构：Department of Gastroenterology and HepatologyNepean HospitalKingswoodAustralia Nepean Clinical SchoolUniversity of SydneyKingswoodAustralia NHMRC Centre of Research Excellence in Digestive HealthHunter Medical Research InstituteThe University of NewcastleNewcastleAustralia
出 版 物：《iLIVER》 (国际肝胆健康（英文）)
年 卷 期：2023年第2卷第2期
页 面：122-129页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Drug-induced liver injury Idiosyncratic hepatotoxicity Acute liver failure Liver-related death Meta-analysis
摘 要：Background and aims:Drug-induced liver injury(DILI)is a leading cause of death from acute liver failure(ALF).Hy s law warns that a hepatocellular pattern of injury accompanied by jaundice and normal alkaline phosphatase(ALP)levels is associated with a 10%or greater chance of progression to transplant or liver-related *** meta-analysis of DILI studies evaluates acute and chronic outcomes of DILI according to clinical pattern of ***:We conducted a systematic search using electronic databases PubMed and EMBASE through to 8 March *** primary outcome was to compare acute outcomes including ALF,liver-related death,and liver transplant between patients experiencing hepatocellular,cholestatic,and mixed patterns of *** secondary outcome was to compare the rate of DILI chronicity between patients of these three differing patterns of *** odds ratios(ORs)and 95%confidence intervals(CIs)were calculated using a random-effects ***:Overall,12 studies comprising 4290 patients were *** with cholestatic DILI demonstrated similar rates of ALF(OR:0.80,95%CI:0.46–1.40,p=0.429)and liver-related death(OR:0.92,95%CI:0.50–1.69,p=0.792)compared to patients with hepatocellular *** with cholestatic DILI were significantly more likely to experience chronicity compared to patients with hepatocellular DILI(OR:2.53,95%CI:1.34–4.79,p=0.004).
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