Norditerpenoid Alkaloids from Aconitum spicatum Stapf

作     者：Li-Ming Gao Hai-Yan Yan Yang-Qing He Xiao-Mei Wei 

作者机构：Department of Chemistry Key Laboratory of Polymer Materials of Gansu Province Northwest Normal University Lanzhou 730070 China 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2006年第48卷第3期

页      面：364-369页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 10[医学] 

主　　题：Aconitum spicatum cytotoxic activity norditerpenoid alkaloids spicatine A spicatine B. 

摘      要：To search for pharmacologically and structurally interesting substances from traditional Chinese medicines, we Investigated the chemical compounds of Aconitum spicatum Stapf. Two new nordlterpenold alkaloids, namely spicatlne A （compound 1） and splcatine B （compound 2）, as well as 11 known norditerpenoid alkaloids were Isolated from the CHCIs portion of the 90% ethanol extract of the roots of A. spicatum. The structures of the alkaloids were characterized on the basis of their spectral data. One of the Isolated compounds showed significant cytotoxic activities （IC50 values 〈 200μmol/l.） against the HL-60 cell line.