Proteomic Analysis of the Small Intestine Reveals Adaptive Strategies for Energy Restriction of Phrynocephalus vlangalii at High Altitude
作者机构：Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental PollutionSchool of Life SciencesLanzhou UniversityLanzhou 730000GansuChina
出 版 物：《Asian Herpetological Research》 (亚洲两栖爬行动物研究（英文版）)
年 卷 期：2023年第14卷第2期
页 面：167-174页
核心收录：
基 金：supported by the National Natural Science Foundation of China(Nos.31471988 and 31200287)
主 题：energy intake energy limitation high altitude label-free proteomic analysis lipid metabolism Phrynocephalus vlangalii
摘 要：The environmental characteristics of hypothermia and hypoxia exert great selective pressure on the energy metabolism of high-altitude animals,especially the *** research on energy-limited adaptation of high-altitude ectotherms has focused on energy ***,the mechanisms of increasing energy intake in high-altitude ectotherms have been studied *** order to investigate the adaptation mechanism of the small intestine,the key part of energy acquisition for animals,to energy limitation at high altitude in ectotherms,the gut proteins of Phrynocephalus vlangalii from high-and low-altitude populations were compared using label free *** enrichment and KEGG pathway analysis showed that proteins associated with energy intake,such as those involved in oxidation-reduction processes,glutathione metabolism,oxidoreductase activity,cofactor binding,catalytic activity and metabolic pathways,were significantly up-regulated in high-altitude populations;while proteins associated with energy expenditure,such as immune responses and processes,membrane attack complexes,natural killer pathway and other immune-related processes,were significantly down-regulated in expression.
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