Multiphysics numerical investigation of photothermal self-driving characteristics of SiO_(2)@Au Janus microparticles for drug delivery
作者机构：School of Energy Science and EngineeringHarbin Institute of TechnologyHarbin150001China Heilongjiang Key Laboratory of New Energy Storage Materials and ProcessesSchool of Energy Science and EngineeringHarbin Institute of TechnologyHarbin50001China
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2023年第76卷第5期
页 面：165-175页
核心收录：
学科分类：0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学]
基 金：supported by the Heilongjiang Province Natural Science Foundation(Grant No.LH2019E053) Fundamental Research Funds for Central Universities(Grant No.FRFCU5710051421).
主 题：Janus microparticles Photothermal self-driving Multiphysics coupling method Brownian
摘 要：The photothermal self-driving process of Janus microparticles has wide application prospects in the fields of biomedicine.Since silica and gold have good biocompatibility and high photothermal conversion efficiency,the SiO_(2)@Au Janus microparticles are widely used as drug carriers.Based on the multiphysics coupling method,the photothermal self-driving process of SiO_(2)@Au Janus microparticles was investi-gated,wherein the substrate was SiO_(2)particles and one side of the particles was coated with gold film.Under a continuous wave laser with irradiation of 20 W/cm^(2),the distance covered by the Janus particles was increased by increasing the thickness of the gold film and reducing the size of the SiO_(2)particles;the self-driving characteristics of the Janus particles were controlled substantially by increasing the intensity of the incident laser.Based on the simulation results,the thermophoretic motion and Brownian motion of particles can be measured by comparing the absolute values of the thermophoretic force impulse,Brownian force impulse,and drag force impulse.The Brownian force acting on Janus microparticles under low laser power cannot be ignored.Furthermore,the minimum laser power required for Janus particles to overcome Brownian motion was calculated.The results can effectively guide the design of Janus particles in biomedicine and systematically analyze the mechanism of particle thermophoretic motion during drug delivery.
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