Epidemiology of perforated peptic ulcer:Age-and gender-adjusted analysis of incidence and mortality

作     者：Kenneth Thorsen Jon Arne Sreide Jan Terje Kvaly Tom Glomsaker Kjetil Sreide 

作者机构：Department of SurgeryStavanger University HospitalN-4068 StavangerNorway Department of Surgical ScienceUniversity of Bergen5020 BergenNorway Department of Mathematics and Natural ScienceUniversity of Stavanger4036 StavangerNorway 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第3期

页      面：347-354页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Perforated peptic ulcer Epidemiology Incidence Mortality Seasonal variation 

摘      要：AIM:To investigate the epidemiological trends in inci-dence and mortality of perforated peptic ulcer(PPU)in a well-defined Norwegian population. METHODS:A retrospective,population-based,single-center,consecutive cohort study of all patients diag-nosed with benign perforated peptic *** were both gastric and duodenal ulcer patients admitted to Stavanger University Hospital between January 2001 and December *** with a malignant neoplasia diagnosis,verified by histology after biopsy or resection,were *** were identified from the hospitals administrative electronic database using pertinent ICD-9 and ICD-10 codes(K25.1,K25.2,K25.5, K25.6,K26.1,K26.2,K26.5,K26.6).Additional searches using appropriate codes for relevant laparoscopic and open surgical procedures(e.g.,JDA 60,JDA 61,JDH 70 and JDH 71)were performed to enable a complete identification of all *** demographics,presentation patterns and clinical data were retrieved from hospital records and surgical *** and adjusted incidence and mortality rates were estimated by using national population demographics data. RESULTS:In the study period,a total of 172 patients with PPU were *** adjusted incidence rate for the overall 10-year period was 6.5 per 100 000 per year(95%CI:5.6-7.6)and the adjusted mortality rate for the overall 10-year period was 1.1 per 100 000 per year(95%CI:0.7-1.6).A non-significant decline in ad-justed incidence rate from 9.7 to 5.6 occurred during the *** standardized mortality ratio for the whole study period was 5.7(95%CI:3.9-8.2),while the total 30-d mortality was 16.3%.No difference in in-cidence or mortality was found between ***,for patients≥60 years,the incidence increased over 10-fold,and mortality more than 50-fold,compared to younger *** admission rates outside office hours were high with almost two out of three(63%) admissions seen at evening/night time shifts and/or during *** observed season