Quantitative Parameters Analysis for Prenatally Echocardiographic Diagnosis of Atrioventricular Septal Defects

作     者：Xiaoxue Zhou Tingyang Yang Ye Zhang Yanping Ruan Jiancheng Han Xiaowei Liu Ying Zhao Xiaoyan Gu Tingting Liu Hairui Wang Yihua He 

作者机构：Maternal-Fetal Consultation Center of Congenital Heart DiseaseDepartment of EchocardiographyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Software Development EnvironmentBeihang UniversityBeijingChina 

出 版 物：《Congenital Heart Disease》 (先天性心脏病（英文）)

年 卷 期：2023年第18卷第3期

页      面：387-397页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：“Dengfeng”Project of Talent Training Plan of Beijing Medical Management Center(Number DFL20220601) Beijing Municipal Administration of Hospitals Incubating Program(Number PX2023023) National Natural Science Foundation of China(Number 82170301) Beijing Municipal Administration of Hospitals Incubating Program(Number PX2022026) Beijing Natural Science Foundation(Number L222152) the Ethics Committee of Beijing Anzhen Hospital(2020016X) 

主　　题：AVSDs fetus echocardiography Q score quantitative 

摘      要：Background:Atrioventricular septal defects(AVSDs)are screened and diagnosed usually rely on the imaging characteristics of fetal echocardiography(FE).However,diagnosis on images is heavily depended on sonographers’experience and the quantitative data are rarely ***:This study aimed to realize the prenatal diagnosis of AVSDs by analyzing the quantitative data on ***:One hundred and thirteen cardiac quantitative data was analyzed in 370 normal and 49 AVSDs fetuses *** top six with the highest diagnostic accuracy rate were acquired according to the area under the curve(AUC),and the diagnostic value of six variables was ***:Six parameters obtained on the four-chamber view(4CHV),including the atrial to ventricular length ratio in end-diastole(AVLR-ED),AVLR-ED combined with the atrial to ventricular length ratio in end-systole(AVLR-ES),quantile score(Q score)of AVLR-ED,Q score of AVLR-ES,Q score of ventricle length in end-diastole(VL-ED),and AVLR-ES,were the top six with the highest diagnostic value,and the AUC was 0.99(95%CI 0.99–1.00),0.99(95%CI 0.99–1.00),0.99(95%CI 0.98–1.00),0.95(95%CI 0.91–0.99),0.93(95%CI 0.87–0.99),and 0.91(95%CI 0.83–1.00),*** within the 20%false positive rate,the diagnostic sensitivity was greater than 100%,100%,100%,90%,90%,and 88%,***:Six variables could be used for prenatal diagnosis of *** them,AVLR-ED and Q score of AVLR-ED,obtained on the 4CHV,were more convenient to acquire and had higher diagnostic accuracy.