Association of vitamin D and polymorphisms of its receptor with antiviral therapy in pregnant women with hepatitis B

作     者：Rui Wang Xia Zhu Xuan Zhang Huan Liu Yu-Lin Ji Yong-Hua Chen 

作者机构：Division of Pancreatic SurgeryDepartment of General SurgeryWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Center of Infectious DiseasesWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Respiratory and Critical Care MedicineWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第19期

页      面：3003-3012页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by the Key Research and Development Projects in Sichuan Province,No.2021YFS0168 the National Scientific and Technological Major Project for Infectious Diseases Control in China,No.2018ZX10715-003 

主　　题：Hepatitis B virus Vitamin D Vitamin D receptor polymorphism Antiviral therapy Pregnancy Mother-to-child transmission 

摘      要：BACKGROUND The interruption of mother-to-child transmission(MTCT)is considered important to decrease the individual and population morbidity of hepatitis B virus(HBV)infection as well as the global burden of hepatitis *** vitamin D(VD)is associated with hepatitis *** To assess whether baseline VD levels and single nucleotide polymorphisms of the VD receptor gene(VDR SNPs)are associated with the efficacy of tenofovir disoproxil fumarate(TDF)in the prevention of MTCT in pregnant women with high HBV viral *** Thirty-eight pregnant women who were at high risk for MTCT of HBV(those with an HBV DNA level≥2×10^(5)IU/mL during 12-24 wk of gestation)receiving antiviral therapy of TDF between June 1,2019 and June 30,2021 in Mianyang were included in this retrospective *** women received 300 mg TDF once daily from gestational weeks 24-28 until 3 mo after *** further characterize the clinical relevance of maternal serum HBV DNA levels,we stratified patients according to HBV DNA level as follows:Those with levels2×10_(5)(full responder group)vs those levels≥2×10^(5)IU/mL(partial responder group)at *** levels of 25-hydroxyvitamin D[25(OH)D],liver function markers,virological parameters,VDR SNPs and other clinical parameters were collected to analyze their association with the efficacy of *** Mann-Whitney U test or t test was used to analyze the serum levels of 25(OH)D in different *** linear regressions were utilized to analyze the determinants of the maternal HBV DNA level at *** and multivariate logistic regression analyses were employed to explore the association of targeted antiviral effects with various characteristics at baseline and *** A total of 38 pregnant women in Mianyang City at high risk for MTCT of HBV were enrolled in the *** MTCT rate was 0%.No mother achieved hepatitis B e antigen or hepatitis B surface antigen(HBsAg)clearance at ***-three(60.5%)participants