Effects of coronavirus disease 2019 vaccination on seizures in patients with epilepsy

作     者：Xiqin Fang Shan Qiao Ranran Zhang Tingting Yang Zhihao Wang Qingxia Kong Meihua Sun Jianhong Geng Chunyan Fang Yanxiu Chen Yanping Sun Dongmei Zhang Lixing Qu Wei Shang Jianguo Wang Xuewu Liu 

作者机构：Department of NeurologyQilu Hospital of Shandong UniversityJinanShandong 250000China Department of NeurologyInstitute of EpilepsyShandong UniversityJinanShandong 250000China Department of NeurologyThe First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China Department of NeurologyAffiliated Hospital of Jining Medical CollegeJiningShandong 272000China Department of NeurologyTengzhou Central People’s HospitalJiningShandong 277599China Department of NeurologyAffiliated Hospital of Weifang Medical CollegeWeifangShandong 261000China Department of NeurologyZhucheng People’s HospitalWeifangShandong 262200China Department of NeurologyLiaocheng People’s HospitalLiaochengShandong 252000China Department of NeurologyAffiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Department of NeurologyLinyi People’s HospitalLinyiShandong 276000China Department of NeurologyDezhou People’s HospitalDezhouShandong 253000China Department of NeurologySecond Hospital of Shandong UniversityJinanShandong 250000China Department of NeurologyJinan Central HospitalJinanShandong 250000China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第5期

页      面：571-577页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100204[医学-神经病学] 10[医学] 

基　　金：National Natural Science Foundation of China(No.81873786) 

主　　题：Coronavirus disease 2019 Electroencephalogram Seizure Vaccine 

摘      要：Background:Given that seizures may be triggered by vaccination,this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy(PWE)after being vaccinated against coronavirus disease 2019(COVID-19).Methods:This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in China.We divided the PWE into two groups as follows:(1)patients who developed seizures within 14 days of vaccination were assigned to the SAV(with seizures after vaccination)group;(2)patients who were seizure-free within 14 days of vaccination were assigned to the SFAV(seizure-free after vaccination)group.To identify potential risk factors for seizure reccurence,the binary logistic regression analysis was performed.Besides,67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence,and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or withdrawal.Results:The study included a total of 407 patients;of which,48(11.8%)developed seizures within 14 days after vaccination(SAV group),whereas 359(88.2%)remained seizure-free(SFAV group).The binary logistic regression analysis revealed that duration of seizure freedom(P3 months before vaccination should be vaccinated.Whether the remaining PWE should be vaccinated depends on the local prevalence of COVID-19.Finally,PWE should avoid discontinuing ASMs or reducing their dosage during the peri-vaccination period.