Circadian clock and temporal meal pattern
作者机构：Department of Medicine-EndocrinologyDiabetesand MetabolismBaylor College of MedicineHoustonTXUSA Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTXUSA Department of Medicine-EndocrinologyDiabetesand MetabolismBaylor College of Medicine1 Baylor Plz MS185HoustonTX 77030USA Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2023年第3卷第1期
页 面：85-101页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by NIH(DK111436,HL153320,AG069966,and ES027544) the John S.Dunn Foundation,the Mrs.Clifford Elder White Graham Endowed Research Fund,theDan L Duncan Comprehensive Cancer Center(P30CA125123) the Texas Medical Center Digestive Diseases Center(P30DK056338) the SPORE program in lymphoma at Baylor College of Medicine(P50 CA126752) the Gulf Coast Center for Precision Environmental Health(P30ES030285)
主 题：cardiometabolic circadian rhythm daily variation diabetes meal response suprachiasmatic nuclei
摘 要：The central circadian clock in the brain controls the time-of-the-day variations in acute meal responses,with a low glycemic response but a high satiety/thermo-genic response to meals consumed at waking compared to other time ***,studies show that consuming a significant proportion of calories,particularly carbohydrates,in breakfast is beneficial for the chronic management of obesity and its associated metabolic syndrome,compared to consuming identical meals at ***,breakfast skipping or/and late dinner can have unfavorable metabolic *** remains controversial how meal frequency affects metabolic *** contrast,irregular meals,especially irregular breakfasts,show consistent adverse metabolic ***-restricted feeding(TRF),with all calories consumed within less than 12-h per day,can improve metabolism and extend lifespan.A major component of TRF in humans is caloric restriction,which contributes significantly to the beneficial effects of TRF in *** comparison,TRF effects in rodents can be independent of caloric restriction and show day/night phase *** could alleviate metabolic abnormalities due to circadian disruption,but its effects appear independent of the circadian clock in *** neuroendocrine mechanisms underlying clock-mediated metabolic regulation will shed light on the metabolic effects of temporal meal patterns.
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