Polygalacin D inhibits the growth of hepatocellular carcinoma cells through BNIP3L-mediated mitophagy and endogenous apoptosis pathways

作     者：NAN Fulong NAN Wenlong YU Zhongjie WANG Hui CUI Xiaoni JIANG Shasha ZHANG Xianjuan LI Jun WANG Zhifei ZHANG Shuyun WANG Bin LI Yiquan NAN Fulong;NAN Wenlong;YU Zhongjie;WANG Hui;CUI Xiaoni;JIANG Shasha;ZHANG Xianjuan;LI Jun;WANG Zhifei;ZHANG Shuyun;WANG Bin;LI Yiquan

作者机构：Department of Special MedicineDepartment of Pathogenic BiologySchool of Basic MedicineQingdao UniversityQingdao 266000China China Animal Health and Epidemiology CenterQingdao 266000China Sino-Cell Biomed Co.Ltd.Qingdao 266000China Academician Workstation of Jilin ProvinceChangchun University of Chinese MedicineChangchun 130000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2023年第21卷第5期

页      面：346-358页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Jilin Province Traditional Chinese Medicine Science and Technology Project(No.2022124) the Science Technology Research Project of Jilin Provincial Department of Education(No.JJKH20220873KJ) the Young Scientist Program Training Program of Changchun University of Chinese Medicine(No.QNKXJ2-2021ZR13) the Natural Science Foundation of Jilin Province(No.YDZJ202201ZYTS257) 

主　　题：Platycodon grandiflorum Apoptosis Autophagy Hepatocellular carcinoma Polygalacin D 

摘      要：Platycodon grandiflorum(Jacq.)*** a famous medicinal plant commonly used in East *** saponins isolated from *** are the main biologically active compounds,among which polygalacin D(PGD)has been reported to be an anti-tumor ***,its anti-tumor mechanism against hepatocellular carcinoma is *** study aimed to explore the inhibitory effect of PGD in hepatocellular carcinoma cells and related mechanisms of *** found that PGD exerted significant inhibitory effect on hepatocellular carcinoma cells through apoptosis and *** of the expression of apoptosis-related proteins and autophagy-related proteins revealed that this phenomenon was attributed to the mitochondrial apoptosis and mitophagy ***,using specific inhibitors,we found that apoptosis and autophagy had mutually reinforcing *** addition,further analysis of autophagy showed that PGD induced mitophagy by increasing BCL2 interacting protein 3 like(BNIP3L)*** vivo experiments demonstrated that PGD significantly inhibited tumor growth and increased the levels of apoptosis and autophagy in ***,our findings showed that PGD induced cell death of hepatocellular carcinoma cells primarily through mitochondrial apoptosis and mitophagy ***,PGD can be used as an apoptosis and autophagy agonist in the research and development of antitumor agents.